HIV-1和GBV—C合并感染的研究进展

Research progress on the course of HIV-1 patients with GBV-C positive infection

研究发现，持续的GBV-C病毒血症和HIV-1感染者长期存活有显著关系，目前对其保护性作用机制了解甚少，可能是GBV-C通过调节化学因子和细胞因子或其受体的表达来实现的。相反的是，有些研究则未观察到GBV—C感染对HIV-1疾病的进展产生有利影响。此文对HIV-1／GBV-C合并感染的流行特点、合并感染对病程进展的影响及GBV-C感染对艾滋病进展的作用机制进行了综述。

Many observations showed that persistent GBV-C viremia could take beneficial effects on HIV-1 survival. The protection mechanisms of GBV-C on HIV-1 are very little known, some researchers beheve that perhaps GBV-C can regulate the secretion and expression of chemokines and cytokines or their equivalent receptors in HIV-1 patients. Contrary to these, some investigations don＇t indicate GBV-C co-infection Can take advantageous effects on the disease progression of HIV-1 patients. In this article, we review the epidemic character of HIV-1/GBV-C co-infection, the effect of co-infection on the disease progress and the role of GBV-C infection on AIDS outcome.