侵袭性肺曲霉病的早期诊断

Early diagnosis of invasive pulmonary aspergillosis

近年来，由于免疫抑制剂及抗生素的广泛应用，侵袭性肺曲霉病（IPA）发病率逐年上升，病死率高，早期诊断及有效治疗可提高患者生存率。传统的诊断方法（如培养法）敏感性低，而组织病理检查有创伤性，因此目前多采用非培养方法（如PCR法、ELISA法、高螺旋CT）进行治疗指导、动态监测及疗效评估。此文对早期诊断的几种方法进行了综述。

Recently, because the wide use of immune inhabitor and antibiotics, the incidence of invasive pulmonary aspergiUosis（IPA） become much higher than before. IPA has high mortality rate,early diagnosis and therapy can improve the patient survival rates. Traditional methods such as culture has low sensitivity, pathology and histology examine has some damage, therefore nonculture methods, like PCR, ELISA and CT are now used to guide and evaluate the curative effect. In the review, we summarize the ways of early diagnosis for IPA.