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IFN-γ、ADA在胸腔积液鉴别诊断的临床评价

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摘要 目的研究胸腔积液中干扰素-γ(IFN-γ)的表达水平及其检测对鉴别良、恶性胸腔积液的临床意义。方法采用双抗体夹心酶联免疫吸附实验(ELISA)法和酚钠试剂显色法分别检测49例胸腔积液(18例结核性胸腔积液、20例恶性胸腔积液、8例类肺炎性胸腔积液、3例漏出液)中的IFN-γ、ADA水平。结果结核性胸腔积液组中的IFN-γ表达水平〔(710±64.8)pg/ml〕最高,与恶性胸腔积液组〔(47.1±21.6)pg/ml〕相比较差异有统计学意义(P<0.001),且IFN-γ的检测对结核性胸腔积液的诊断具有较高的灵敏度和特异度,分别为94.4%和96.8%,两者均高于结核性胸腔积液中ADA的检测单独检测IFN-γ与IFN-γ、ADA联合检测相比较,其诊断评价差异无统计学意义(P>0.05)。结论检测胸腔积液中IFN-γ的水平有助于良、恶性胸腔积液的鉴别,对结核性胸腔积液的诊断具有较高的临床价值。
作者 沈维 朱晓多 赵力 程兴梅
机构地区 黑龙江省医院 黑龙江省哈尔滨市红十字急救中心
出处 《中国实用医药》 2008年第11期30-31,共2页 China Practical Medicine
关键词 胸腔积液 干扰素-γ(IFN-γ) 腺苷脱氨酶(ADA)
分类号 R446.6 [医药卫生—诊断学]
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参考文献5

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二级参考文献20

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中国实用医药
2008年 第11期

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