血清中前S1抗原与HBV-DNA、HBeAg检测结果及临床意义的分析

The study of clinical significance of HBV Pre S1-Ag. HBV-DNA and HBeAg in HBV infection

目的对比分析前S1抗原、HBV—DNA和HBeAg在乙型肝炎感染期主要临床意义。方法用酶联免疫吸附法（ELISA）分别检测前S1抗原和乙肝血清标志物“五项”，用荧光定量聚合酶反应（PCR）检测HBV—DNA，对619例乙肝病毒标志物进行检测，检测结果进行统计分析。结果619例中HBV-DNA阳性率78．4％[485／619]，前S1抗原的阳性率为69．34％[429／619]，其中HBeAg阳性／HBeAg阴性[HBeAb阳性]又分为两组，结果：前S1抗原阳性率在EBeAg阳性模式组中明显高于HBeAg阴性／抗HBeAb阳性模式组，前S1抗原与HBV—DNA和HBeAg检测有明显相关性和互补性。结论前S1抗原的检测可以较好的反映HBV存在和复制的情况，前S1抗原作为辅助或补充指标联合HBV血清标志物与HBV—DNA同步动态监测，为乙型肝炎的诊断、治疗和预后判断提供依据，具有重要临床价值。

Objective To study the clinical significance of HBV Pre SI-Ag, HBV-DNA and HBeAg in HBV infection, Methods HBV Pre S1-Ag and the serum markers of hepatitis B were detected by ELISA. HBV-DNA was detected by fluorescence quantitative PCR. The detection results of the 619 cases were analyzed. Results Before treatment to the 619 patients of Hepatitis B virus infection, the positive rate of HBV-DNA was 78.4% and HBV- Pre S1 antigen was 69.34%. The positive rate of HBV Pre S 1-Ag detection in HBeAg （＋） groups is higher than in HBeAg （-） groups. Conclusions The detection of HBV Pre S l-Ag can well reflect the presence and replication of HBV. The synchronous dynamic detection of PreS 1-Ag, HBV markers and HBV-DNA has its imoortant clinical meaning.