摘要
痤疮属于毛囊皮脂腺单位慢性炎性疾病。近来的研究表明,痤疮的发病机制中免疫应答与毛囊皮脂腺单位高表达白细胞介素1α、Toll样受体、可溶性白细胞介素2受体有关。痤疮瘢痕愈合的炎症皮损在消退期呈现高比例的皮肤归巢T细胞、巨噬细胞浸润、人类白细胞抗原高表达及毛细血管增生,提示迟发型超敏反应参与痤疮的炎症机制,免疫失衡在痤疮炎症发展中可能起关键性作用。
Acne is a chronic inflammatory disease of the pilosebaceous follicle. The significant expression of interleukin 1 alpha-induced in the pilosebaceous unit,Toll-like receptors （TLRs）, and soluble interleukin-2 receptors are considered to be involved in the pathogenesis of acne. A high percentage of skin homing T-cells, macrophages infiltration, strong expression of HLA-DR, and angiogenesis proliferation are symptoms in the retreat of the lesions with acne scars. It shows that delayed-type hypersensitivity is considered to be involved in the pathogenesis of acne and unbalanced humoral and cellular play major roles in inflammatorv acne.
出处
《医学综述》
2008年第8期1124-1126,共3页
Medical Recapitulate
基金
南宁市科学研究与技术开发计划项目(2007011421C)
