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类风湿性关节炎中破骨细胞基质金属蛋白酶9的研究进展 被引量：4

The Research Progress of Matrix Metalloproteinase-9 Secreted by Osteoclast in Rheumatoid Arthritis
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摘要 类风湿性关节炎骨质侵蚀与关节破坏是近年来研究的热点。目前,已经知道破骨细胞是导致关节侵蚀的主要细胞,而基质金属蛋白酶9(MMP-9)在破骨细胞中高表达,在细胞外间质的降解中发挥重要作用。破骨细胞分化过程中,MMP-9基因表达受到多种因素的调控。现将近几年MMP-9在类风湿性关节炎发生发展中的作用及其调控机制等予以综述。 Osseous erosion and joint damage in rheumatoid arthritis become an investigative hot spots in recent years. It is known that osteoclast is the main cell causing osseous erosion, while matrix metalloproteinase-9 highly expressed in osteoclast, plays an important role in extracellular matrix degradation. The gene expression of MMP-9 is regulated by several factors. This article reviewed the role of MMP-9 expression in osteoclast and its regulation mechanism in recent years.
作者 李萍 刘力 王文杰
机构地区 西南大学动物科技学院 中国医学科学院中国协和医科大学药物研究所
出处 《医学综述》 2008年第8期1127-1129,共3页 Medical Recapitulate
基金 国家"863"计划资助课题(2002AA233081)
关键词 基质金属蛋白酶9 破骨细胞 关节破坏 类风湿性关节炎 Matrix metalloproteinase-9 Osteoclast Joint destruct Rheumatoid arthritis
分类号 R967 [医药卫生—药理学]
  • 相关文献

参考文献21

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二级参考文献52

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共引文献38

同被引文献40

  • 1王文军,李建军,李小春,冷向阳.Ⅱ型碳酸酐酶阻断剂对体外破骨细胞的抑制作用[J].中国骨伤,2003,16(7):409-411. 被引量：2
  • 2林燕萍,周瑞祥,李异龙,袁俊,黄美雅.健骨颗粒对去卵巢骨质疏松模型鼠尿脱氧吡啶酚及骨组织整合素β_1 mRNA表达的影响[J].中国中西医结合杂志,2006,26(5):435-438. 被引量：13
  • 3庄丽,白玉兴,李俊发.龈沟液中基质金属蛋白酶-9含量与正畸牙根吸收相关性的实验研究[J].北京口腔医学,2007,15(2):65-69. 被引量：13
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引证文献4

二级引证文献18

医学综述
2008年 第8期

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