摘要
蛋白组学是继基因组之后发展起来的一门新的技术学科,它是建立在蛋白质的提取、分离、纯化、鉴定技术之上的。利用蛋白组学技术分析移植患者和其它患者的血清、尿液等体液中蛋白表达的差异,可以发现一些移植相关的特异性蛋白,并制定相应的蛋白组模式,利用这些蛋白组模式可以区别出移植排异患者与非移植排异患者、阐述移植排异的机制、移植耐受的机制。为临床诊断、开辟新的治疗方案提供依据。
Proteomics is a new techniques after the development of genome. It was found on the extraction, abstraction, purification and identification of protein. Using proteomics techniques to analyze the difference of humor proteins between patients transplantation and any other patients, such as serum protein, urine protein and so on,we can find some specific proteins related to transplantation and make some proteomics models. We can identify patients having transplant rejection and patients without transplant rejection by using these proteomics and explain the mechanism of graft rejection and transplantation tolerance, which can offer reference for clinical diagnosis and therapeutic regimen.
出处
《医学综述》
2008年第8期1147-1150,共4页
Medical Recapitulate
关键词
器官移植
蛋白组学
蛋白质分离
Organ transplant
Proteomics
Protein separation
