摘要
原发性高血压是遗传物质与环境共同作用的多基因遗传病,发病率高,危害严重。对其候选基因的研究是阐明其发病机制的基础,也预示着高血压基因治疗的广阔前景,目前候选基因策略的关联分析仍是主流的研究方法。许多研究显示,原发性高血压易感基因的作用在不同人种、民族有显著差异,文章主要针对以中国汉族为对象的,涉及肾素-血管紧张素等系统多个基因及其协同作用的研究进展予以综述。
Essential hypertension is a polygenic disorder with genetic and environmental factors contributing to its high incidence and severe sequences. Studies about its candidate genes is the basis to elucidate its pathogenesiso, which signifies a bright future of gent therapy to essential hypertension. The correlation analysis of the strategy for eandidate gene is the main approach at present. A lot of researches have revealed that the tmderlying genetic pathways of essential hypertension vary with ethnieity and nationality signifieantly. Therefore ,the studies about essential hypertension candidate genes concerning different mechanisms as reninangiotensin system and the gene-gene interaction in Chinese han population are reviewed in this article.
出处
《医学综述》
2008年第8期1158-1161,共4页
Medical Recapitulate
关键词
原发性高血压
候选基因
汉族
协同作用
Essential
hypertension
Candidate genes
Han population
Gene-gene interaction
