摘要
CD151是近年来发现的一个新的癌基因,属于跨膜四蛋白超家族成员,是该家族中惟一的癌基因,能与其他跨膜四蛋白超家族成员和(或)整合素等结合形成复合体,通过蛋白激酶C、磷脂酰肌醇4激酶等信号通路将胞外信号转导入胞内,从而介导细胞的黏附、迁移及血管形成,实现其促进肿瘤细胞侵袭和转移的作用。文章就CD151基因的结构、作用机制及其与肿瘤的关系进行综述。
CD151 gene was a newly found oncogene in recent years. It belongs to the transmembrane 4 superfamily（ TM4SF）, and was the only ongogene in the family, which can combine with other members of TM4SF and many integrin members to form complex, and transduct the extracellular signals into intracellular one by PKC, PI4K signaling,Then it will promote the invasion and metastasis of tumor cell by mediating cell adhension, migration and angiogenesis. This article reviews CD151 about its structure, mechanism of action and its relationship with tumor.
出处
《医学综述》
2008年第8期1165-1168,共4页
Medical Recapitulate
基金
广西自然科学基金资助项目(桂科自0640112)
