摘要
骨桥蛋白是一种磷酸化糖蛋白,是骨骼和牙齿矿化细胞外基质的主要组成成分。它不仅参与骨的吸收与形成,而且与肿瘤的浸润、转移密切相关,是一种新的肿瘤标志物。文章概述了骨桥蛋白的分子生物学特性及其在肿瘤发生、发展中的作用并详述了近年来关于骨桥蛋白与妇科肿瘤关系的研究进展,及其对妇科肿瘤的早期诊断、评价疗效及预后等方面的重要意义。
Osteopontin, a glyeosylated protein with phosphorylation, is a prominent component of extracellular matrix of mineralized tissues of bones and teeth, It not only takes part in the absorption and formation of hone,but also is closely related to invasion and metastasis It is also considered to be a new tumor marker. This article not only reviews osteopontin about its molecular bionomies and effects on the genesis and development of tumor, but also reviews the relationship between osteopontin and geneeologieal tumor and its great significance in the gynecological tumor about its early diagnosis, therapeutic evalustion and prognosis.
出处
《医学综述》
2008年第8期1173-1175,共3页
Medical Recapitulate
关键词
妇科肿瘤
骨桥蛋白
肿瘤标记物
肿瘤转移
预后
Gynecological Tumor
Osteopontin
Tumor marker
Tumor metastasis
Prognosis
