KAI1基因与恶性肿瘤隐匿性淋巴结转移的研究现状

Research Progress of KAI1 Gene in Malignant Tumor Occult Lymphatic Metastasis

恶性肿瘤的转移是患者预后不良的重要原因。如何发现和判断转移是人们研究的热点,特别是肿瘤隐匿性转移的早发现、早诊断、早治疗也越来越受到重视。近年来免疫组织化学和分子生物技术的应用在隐匿性转移的研究中逐渐显示出优势,尤其在DNA和RNA水平上的研究可能提供更多的信息。文章就近年来肿瘤转移抑制基因KAI1在淋巴结隐匿转移中的研究进展进行综述。

Malignant tumor metastasis is an important reason of poor prognosis in cancer patients. The way to find and judge metastasis is the hotspot of the research.Early discovery, early diagnosis, and early treatment of malignant tumor occult metastasis is given serious attention especially. In recent years the application of immunohistochemical technique and molecular biology techniques in occult metastasis research gradually show their advantage,and especially the research on the level of DNA and RNA probably provides more and more information. This artide highlights the recent progress in the study of tumor transfer suppressor gene KAII in occult lymph node metastasis.