乙型肝炎病毒表面抗原与原发性肝癌的相关性分析

Observation on the Correlation between Hepatitis B Surface Antigen and Primary Carcinoma of Liver

目的:观察乙型肝炎病毒表面抗原与原发性肝癌的关联性。方法:采用前瞻性研究,自1996年7月起对观察对象随访10年,其中HBsAg阳性者1472例,阴性者1478例,于2006年10月用流行病学方法分析各种标化死亡比等观察结果。结果:①HBsAg阳性组的肝癌标化死亡比(SMR)男、女分别为8.85与12.50,HBsAg阴性组的肝癌SMR分别为2.87与3.47,两组之间差异显著;②HBsAg与肝癌的关系在前后5年的趋势相似;③HBsAg阴性和阳性组的胃癌及食道癌的标化死亡率无统计学差异。结论:乙型肝炎病毒感染与原发性肝癌发病有关。

Objective： To observe the association between hepatitis B surface antigen （HBsAg） and primary carcinoma of liver. Method： In 2950 subjects,including 1472 HBsAg positive patients and 1478 HB-sAg negative control, all of them were obversved in 10 years and the standardized mortality ratio （ SMR ） of primary carcinoma of liver were calculated in each group. Results： ①In HBsAg positive groups,the SMR were 8.85 in men and 12.50 in women, in HBsAg negative groups, the SMR were 2.87 in men and 3.40 in women, There were significant difference among different groups;②the trend of correlation between HBsAg and primary carcinoma of liver were alike in 5 years before and after;③There were not any significant difference observed about the SMR of carcinoma ventriculi and esophagus cancer in different groups. Conclusion： The infection of hepatitis B virus is one of pathogenies of primary carcinoma of liver.