血脂与急性脑梗死OCSP分型关系分析

Relationship between blood lipids and the oxfordshire community stroke project classification

目的研究血脂与急性脑梗死按牛津郡社区卒中研究分型(OCSP)关系。方法前瞻性连续收集2005年1月1日至12月31日广州医学院第二附属医院神经内科收治的发病7d内住院急性脑梗死患者600例,分析OCSP各亚型间血脂水平的差异。结果腔隙性脑梗死(LACI)患者三酰甘油(TG)水平高于完全前循环梗死(TACI)(P<0.05),LACI患者高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A(ApoA)水平高于TACI患者(P<0.01)。结论TG水平升高患者有发生LACI倾向,HDL-C、ApoA是脑梗死的保护因素,HDL-C、ApoA水平升高患者发生急性脑梗死后病情较轻。

Objective The goal of the present study was to investigate the relationship between the oxfordshire community stroke project classification and blood lipids. Methods We consecutively recruited 600 patients with acute cerebral infarction, whose symptom onset was less than 7 days, admitted in the neurological department of the second affiliated hospital of Guangzhou medical college. The difference of blood lipids between the oxfordshire community stroke project classification was analyzed. Results Patients with lacunar infarcts（LACI） had significantly higher serum triglyceride（TG） level than patients with total anterior circulation infarcts（TACI） （ P 〈0, 05 ）. Serum high -density lipoprotein cholestero（ HDL - C） and apolipoprotein A（ APO A） in LACI were higher than TACI（ P 〈 0.01 ）. Conclusion The results of our study support that a higher level of TG, HDL - C and Apo A favors development of minor strokes.