期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

MIC-1、uPA蛋白在胃癌中的表达及临床意义 被引量：4

Expression of Macrophage Inhibitory Gytokine-1 (MIC-1) and Urokinase-type Plasminogen Activator (uPA) in Gastric Cancer and Its Significance
下载PDF
导出
摘要 [目的]观察MIC-1和uPA在胃癌组织中的表达特点,探讨两指标在胃癌发生、发展中的分子机制及相关性。[方法]用免疫组织化学SP方法测定正常胃黏膜30例,胃炎组织12例,胃癌组织76例,石蜡标本中MIC-1和uPA蛋白的表达水平。[结果]MIC-1及uPA蛋白在胃癌组织中的阳性表达率明显高于正常胃黏膜组和胃炎组,有显著性差异(P<0.05),而在正常胃黏膜组和胃炎组间其表达率无统计学差异(P>0.05)。胃癌组织中,MIC-1及uPA蛋白表达水平与胃癌浸润深度、淋巴结转移及临床TNM分期呈正相关,有显著性差异(P<0.01),与性别、年龄、肿瘤部位、肿瘤大小、Borrmann分型、病理分化程度无相关性(P>0.05)。76例胃癌组织标本中MIC-1、uPA表达共阳性者43例,共阴性者16例,两者的表达呈正相关(P<0.01)。[结论]MIC-1和uPA可能与胃癌的发生发展有关。在胃癌组织中MIC-1与uPA蛋白表达呈正相关。
作者 栾天燕 刘巍 杨渤彦 王志宇 王亚茹 韩强 张兰凤 程魏
机构地区 河北省保定市第三医院
出处 《肿瘤学杂志》 CAS 2008年第4期267-269,共3页 Journal of Chinese Oncology
关键词 胃肿瘤 MIC-1 UPA 免疫组织化学
分类号 R735.2 [医药卫生—肿瘤]
  • 相关文献

参考文献9

  • 1Bauskin AR, Brown DA, Junankar S, et al. The propeptide mediates formation of stromal stores of PROMIC-1: role in determining prostate cancer outcome[J]. Cancer Res, 2005, 65(6):2330-2336.
  • 2Herszlyi L, Plebani M, Cardin R, et al. The role of urokinase-type plasminogen activator and its inhibitor PAI-1 in gastric cancer[J]. Acta Physiol Hung, 1995, 83(3):213- 221.
  • 3Bootcov MR, Bauskin AR, Valenzuela SM, et al. MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily[J]. Proc Natl Acad Sci USA, 1997, 94(21):11514-11519.
  • 4Schober A,Bottner M,Strelau J, et al. Expression of growth differentiation f actor-15/macrophage inhibitory cytokine- 1 (GDF-15/MIC-1) in the perinatal, adult, and injured rat brain[J]. J Comp Neurol, 2001, 439(1):32-45.
  • 5Brown DA, Stephan C, Ward RL, et al. Measurement of serum levels of macrophage inhibitory cytokine 1 combined with prostate-specific antigen improves prostate cancer diagnosis[J]. Clin Cancer Res, 2006, 12(1):89-96.
  • 6Brown DA, Ward RL, Buckhauhs P, et al. MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma[J]. Clin Cancer Res, 2003, 9 (7):2642-2650.
  • 7Koopmann J,Rosenzweig CN, Zhang Z, et al. Serum markers in patients with resectable pancreatic adenocarcinoma: macrophage inhibitory cytokine 1 versus CA19-9[J]. Clin Cancer Res, 2006, 12(2):442-446.
  • 8Lee DH, Yang Y, Lee SJ, et al. Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells by up-regulating the urokinase-type plasminogen activator system[J]. Cancer Res, 2003, 63(15):4648-4655.
  • 9Macchione E,Epifano O, Stefanini M, et al. Urokinase redistribution from the secreted to cell-bound fraction in granulosa cells of rat preovulatory follicles[J]. Biol Reprod, 2000, 62(4):895.

同被引文献33

  • 1杨聪颖,陈昊,张昶,王巧,白玲,孟建.乳腺癌中TOPOⅡ、GST-π、雌激素受体、C-erbB-2癌基因的表达及相互关系[J].宁夏医学院学报,2004,26(5):317-319. 被引量：5
  • 2曲延刚,唐爱萍,綦瑶.乳腺癌中LRP、GST-π、TOPOⅡ的表达及临床意义[J].中国厂矿医学,2005,18(3):195-197. 被引量：6
  • 3张江兰,陈秀玲,薄爱华,张晓丽,邢立强.DNA拓扑异构酶Ⅱ在膀胱癌中表达的临床意义[J].河北北方学院学报（医学版）,2005,22(3):14-15. 被引量：2
  • 4许春进,陈玉龙,韩敏,李扬帆.转化生长因子β_1和磷酸化细胞外信号调节激酶在胃癌中的表达[J].中华内科杂志,2006,45(7):586-587. 被引量：6
  • 5Grqndpre T, Li S, Strittmatter SM. Nogo - 66 receptor antagonist peptide promotes axonal regeneration [ J ]. Nature, 2002, 417 (6888) :547 - 551.
  • 6Bardou VJ, Arpino G, Elledge RM, et al. Progesterone receptor status significantly improves outcome prediction over estrogen receptor status alone for adjuvant endocrine therapy in two large breast cancer databases[ J]. J Clin 0ncol,2003,21:1973 - 1979.
  • 7Bootcov MR, Bauskin AR, Valenzuela SM, et al. MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF- beta superfamily. Proc Natl Acad Sci U S A, 1997,94 (21) : 11514-11519.
  • 8Bauskin AR, Brown DA, Junankar S, et al. The propeptide mediates formation of stromal stores of PROMIC-1 : role in determining prostate cancer outcome. Cancer Res,2005,65 (6) :2330-2336.
  • 9Bauskin AR, Brown DA, Kuffner T, et al. Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer. Cancer Res,2006,6(10) :4983-4986.
  • 10Brown DA, Stephan C,Ward RL, et al. Measurement of serum levels of macrophage inhibitory cytokine 1 combined with prostatespecific antigen improves prostate cancer diagnosis. Clin Cancer Res,2006,12( 1 ) :89-96.

引证文献4

二级引证文献9

肿瘤学杂志
2008年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部