摘要
内皮素(ET)在喘息性疾病患儿血浆中高水平表达,作为血管及支气管平滑肌收缩剂,激活受体,刺激呼吸道细胞分泌各种炎症介质,使呼吸道上皮细胞及平滑肌细胞增殖、迁移异常,导致呼吸道重塑。在喘息性疾病中起到病理生理作用。ET与喘息性疾病密切相关,检测ET的水平对判断喘息性疾病的病情、严重度和防治有一定的指导意义。
ET has a high level expression in children with asthmatic diseases. As a constraction agent of blood vessel and bronch-tracheal smooth muscle activates acceptors, ET stimulates the cells of vespiratory tract to secrecte various of inflammaory mediators and makes epithelial cells and somooth muscle cells of respiratory tract profiferate or migrate abnormaly, and then lead to the remold of the respiratory tract. ET actsa pathophysilogical role in asthmatic diseases in children and is closely related to asthmatic diseases. The detection of the level of ET has instructed significance in judging the condition,sevrity, prevention and treatment of asthmatic diseases in chidren.
出处
《现代诊断与治疗》
CAS
2008年第2期95-97,共3页
Modern Diagnosis and Treatment
