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伊曲康唑连续疗法与冲击疗法治疗儿童白癣的疗效比较 被引量:2

Optimum regimen for tinea capitis of childhood with itraconazole:continuous or pulse therapy
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摘要 目的:探索伊曲康唑治疗儿童白癣的优化方案.方法:93例明确诊断的白癣患儿随机分为2组.治疗组51例,给予伊曲康唑胶囊冲击疗法:5mg/kg,口服,1次/d,服药1wk,停药1wk,同时给予30g/L碘酊,涂患处,2次/d,50g/L水杨酸软膏与50g/L硫磺软膏等量混合后涂患处,2次/d,4wk为1个疗程;对照组42例,给予伊曲康唑胶囊连续疗法:5mg/kg,1次/d,外用药同治疗组,4wk为1个疗程.治疗结束后每2wk随访1次,每次随访时进行真菌镜检、培养,至治疗结束后6mo,对于随访过程中真菌学阳性的患儿,按原治疗方案继续服药2wk.结果:在服药4wk时,临床及真菌学痊愈(率):治疗组49例(96.08%),对照组41例(97.62%),二者之间无统计学差异(P>0.05).治疗组2(3.92%)例患儿出现不良反应,对照组为5(11.90%)例,其发病率明显高于治疗组(P<0.05).结论:伊曲康唑治疗儿童白癣安全、有效、疗程短;冲击疗法比连续疗法更经济. AIM: To explore the optimum regimen for tinea capitis of childhood with itraconazole. METHODS : A prospective, randomized, open parallel controlled clinical trial was conducted. A total of 93 cases of tinea capitis of childhood were divided into 2 groups. Itraconazole capsules 5 mg/kg · d were given orally once every day for every other week in pulse therapy group ( n = 51 ) and every day in continuous therapy group ( n = 42 ), with 4 weeks as a course of treatment. Concomitant topical therapy was composed of 30 g/L iodine lotion used twice daily, and equivalent admixture of 50 g/L salicylic ointment and 50 g/L sulphur ointment used twice daily. The follow-up was conducted every 2 weeks for mycological examination until 6 months after treatment. If the mycological examination showed positive in the follow-ups, the other 2-week same treatment was given until the mycological examination became negative. RESULTS: At the 4th weeks, 49 cases(96.08% )in pulse therapy group and 41 cases( 97.62% ) in continuous therapy group were cured and presented negative in clinical and mycological examinations, and there was no statistical difference between the 2 groups ( P 〉 0.05 ). Side effect occurred in 2 cases (3.92%) of pulse therapy group and in 5 cases ( 11. 90% ) of continuous therapy group, and the incidence of side effect was significantly lower in pulse therapy group than in continuous therapy group ( P 〈 0.05 ). CONCLUSION: Itraconozole is safe and effective and of shorter treatment period for the tinea capitis of children. Pulse therapy is more economical than continuous therapy.
出处 《第四军医大学学报》 北大核心 2008年第8期719-721,共3页 Journal of the Fourth Military Medical University
关键词 白癣 冲击疗法 伊曲康唑 tinea capitis pulse therapy itraconazole
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  • 1Mohrenschlnger M,Schnopp C,Fesq H,et al.Optimizing the therapeutic approach in tinea capitis of childhood with itraconazole[J].Br J Dermatol,2000,143(5):1011-1015.
  • 2Gupta AK,Ginter G.Itraconazole is effective in the treatment of tinea capitis caused by Microsporum canis[J].Pediatr Dennatol,2001,18(6):519-522.
  • 3Ginter-Hanselmayer G,Smolle J,Gupta A.Itraconazole in the treatment of tinea capitis caused by Microsporum canis:experience in a large cohort[J].Pediatr Dermatol,2004,21(4):499-502.

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