线粒体脑肌病患者癫特点分析

Features of epileptic seizures in patients with mitochondrial encephalomyopathy

目的探索线粒体脑肌病患者癫发作特点。方法结合脑电图、头颅MRI检查结果,对9例明确诊断为线粒体脑肌病患者的癫发作特征、发作类型进行总结分析。结果9例患者累计癫发作17次,其中70.6%(12/17)为频繁发作。性发作表现为多种形式,其中视觉症状多见,占29.4%(5/17)。结合脑电图结果分析,局灶性癫发作78.6%(11/14),全面性癫发作14.3%(2/14),持续性癫发作占7.1%(1/14);枕叶癫占41.2%(12/17),颞叶癫占11.8%(2/17),额叶或顶叶癫17.6%(3/17),与MRI显示的颅内病灶相一致。结论线粒体脑肌病患者的癫发作,较为频繁,以视觉症状为突出表现;以局灶性发作,枕叶癫多见,与头颅MRI结果相一致。

Objective To study the features of epileptic seizures in patients with mitoehondrial encephalomyopathy.Methods Nine patients were diagnosed as having mitoehondrial eneephalomyopathy through muscle biopsy. Integrating EEG and MPd, we studied the features of their epileptic seizures. Results Twelve frequent seizures comprised 70.6% of 17 epileptic seizures in the nine patients. Visual symptom was the most frequent symptom（ 29.4 %, 5/17）. Referring to eleetroeneephalogram, focal seizure （ 11 / 14,78.6 % ） and occipital lobe seizure （ 12/17,41.2 % ） were the most frequent seizure types, consistent with the brain lesion displayed by MRI. Conclusions Focal seizure and occipital lobe seizure are the most frequent epileptic seizure types in patients with mitochondrial encephalomyopathy, which are mild and easy to control.