慢性肝病患者血清载脂蛋白A检测的临床意义

Clinical Significance of Measurement of Serum Apolipoprotein A in Patients with Chronic Liver Diseases

目的探究血清载脂蛋白A含量与患者肝脏损伤程度的关系。方法281例肝病患者(观察组)。检测其血清中TG、HDL、LDL、Tch、APOA1和APOA2的含量;并与49例健康体检者(对照组)的检测结果进行比较分析。结果观察组血清APOAl、APOA2、HDL、LDL均显著低于对照组,差异有统计学意义(P<0.05);血清APOAl、APOA2与HDL、LDL、Tch正相关(P<0.05),与TG无相关性(P>0.05);经ROC曲线评价,APOA1的灵敏度及特异性分别为93.9%和83.6%,APOA2的灵敏度及特异性分别为93.9%和82.2%。结论血清载脂蛋白A可作为判断肝病患者肝脏受损程度及肝脏合成功能的有效指标,值得临床推广。

Objective To To explore the relationship between the serum apolipoprotein A level and hepatic injury in patients. Methods The serum levels of TG, HDL, Tch, APOA1 and APOA2 were measured in 281 patients with chronic liver diseases; then compared with the levels in 49 healthy controls. Results The levels of APOA1, APOA2, HDL and LDL were significantly lower in cases than in controls （P 〈 0.05）. The levels of AOPA1 and AOPA2. were positively correlated with HDL, LDL and Teh, but was not correlated with TG （P〉 0.05）. The sensitivity of AOPA1 and AOPA2. both was 93.9% estimated by ROC curve, while the specificity was 83.6% and 82.2%, respectively. Conclusions The serum apolipoprotein A can be used as effective markers in the evaluation of hepatic injury and hepatic synthetic function.