湿疹消治疗湿疹的药理作用

Effect of Shizhenxiao on Eczema

目的体内外动物实验评价湿疹消防治湿疹的作用以及作用机理。方法运用体外抑菌实验探讨药物的抑菌作用,运用组织胺致豚鼠足瘙痒评价药物的抗过敏作用,用二甲苯致小鼠耳肿胀等炎症模型评价药物的抗炎作用。结果湿疹消可显著提高组织胺致豚鼠足瘙痒阈值,显著抑制角叉菜胶致小鼠足肿胀及二甲苯致小鼠耳肿胀和腹腔通透性增加,与对照组比较均具有统计学意义;同时还对金黄色葡萄球菌、大肠杆菌、铜绿假单胞菌及普通变形杆菌的生长有一定的抑制作用。结论实验结果显示湿疹消对湿疹有一定的防治作用。

Objective To study the effects of Shizhenxiao zema. Method To evaluate the anti-hypersensitive and （a Chinese traditional proprietary medicine） on ecanti-inflammatory effects of Shizhenxiao, the guinea pig foot itch was induced by histamine hydrochloride and mouse ears swell by dimethylbenzene. And the effects of Shizhenxiao on the growth of bacteria were evaluated in vivo. Results Shizhenxiao could increase the itch threshold of guinea pig foot induced by histamine hydrochloride, inhibit the mouse ears swell and abdomen inflammation induced by dimethylbenzene and mouse foot swell induced by carrageen. Shizhenxiao could inhibit the growth of Staphylococcus ausreus, Escherichia coli, Pseudomonas aeruginosa and Proteus vulgaris. Conclusion These results show that Shizhenxiao may be an effective anti-eczema drug.