还原型谷胱甘肽治疗酒精性肝病88例临床分析

Cutative Effect of Reduced Glutathione in 88 Patients with Alcoholic Liver Disease

目的探讨还原型谷胱甘肽治疗酒精性肝病的临床疗效。方法将88例酒精性肝病患者按完全随机对照法分为治疗组45例,给予还原型谷胱甘肽治疗;对照组43例,给予极化液治疗,疗程1个月,观察其临床疗效。结果治疗组临床症状体征及肝功能指标的恢复优于对照组。治疗组治疗后ALT、AST、GGT、TB IL、ALB值较治疗前明显下降(t=10.86,P<0.05),下降幅度大于对照组(t=12.87,P<0.05)。治疗组显效29例(64.4%),有效13例(28.9%),总有效率93.3%;对照组显效18例(41.9%),有效12例(27.9%),总有效率69.8%,2组疗效差异有统计学意义(P<0.05,χ2=14.20)。治疗组和对照组治疗前后消化道症状和乏力差异有统计学意义(P<0.01,P<0.05),腹水征差异无统计学意义(P>0.05)。结论还原型谷胱甘肽治疗酒精性肝病有良好疗效。

Objective To analyze the curative effect of reduced glutathione in the treatment of alcoholic liver disease（ALD）. Method Of 88 patients with ALD were randomly divided into two groups. Forty five patients as treatment group were treated with reduced glutathione, and the other 43 as control group with polarized solution, both for a month. Results The recoveries of clinical symptoms and signs and the hepatic function pararneters of the treatment group were significantly superior than that of the control group. The total curative 2 rate of freatment group （93.3%） was significantly higher than that of control group （69.8%） （P 〈0. 05, χ^2 = 14.20）. Conclusion Reduced glutathione is effective in the treatment of ALD.