运动对p38MAPK表达的影响

Effects of Sports on p38MAPK

丝裂原活化蛋白激酶信号系统(mitogen activated protein kinase,MAPKs)在细胞的信号传导中起着很重要的作用,其中以p38研究得最为深入。:运动是一个非常重要的刺激因素,可对骨骼肌中的多种代谢和转录过程起调节作用。MAPK信号级联中有多种独立的信号途径参与了骨骼肌运动性适应的细胞调控过程,对骨骼肌中葡萄糖转运、胰岛素信号转导、钾离子转运、工作肌的可塑性等产生影响。运动能够激活骨骼肌中MAPKs信号传导系统。不同运动方式、不同类型的肌肉可以影响到MAPKs的激活,而且激活后MAPKs具有不同的时相性。MAPKs对运动后骨骼肌的适应性变化具有重要作用。

MAPKs play important roles in cell signaling pathways. Within p38 became warmer point studies and are better known. Exercise is a very important stimulant aspect,it can regulate metabolize and transcription in skeletal muscle. There have many independent signal paths in MAPK cascade that take part in adapt of skeletal muscle during the cell regulation. These could have effects on glucose transport, insulin signal diversion,k＋ transport and so on. Exercise can stimulate MAPKs. Different kinds of exercise and different types of skeletal muscle effect on stimulating MAPKs. MAPKs are involved in skeletal muscle adaptation and have different time courses after exercise.