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健康更年期后女性AR基因(CAG)n多态性的调查

Study of AR gene(CAG)n repeat sequence polymorphism in healthy postmenopausal women
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摘要 目的研究健康更年期后女性雄激素受体基因(CAG)n重复序列多态性。方法使用DNA测序方法对60例更年期后健康女性AR基因外显子1 NH2端转录调节区内(CAG)n重复序列长度进行测定。结果(1)健康更年期后女性AR基因(cAG)n重复数最短为18,最长为34,平均值为23.34±2.44;(2)更年期后女性(CAG)n重复序列多态性与育龄妇女有差异(P>0.05)。结论(1)健康更年期后女性AR基因(CAG)n重复序列长度存在多态性;(2)健康更年期后女性AR基因(CAG)n的重复数大于育龄期女性。 Objective To analyze CAG length polymorphism of androgen receptor gene in healthy postmenopausal women. Method DNA sequencing of the CAG repeat from which the N-terminal domain of the first exon of the AR gene, were analyzed by applied Biosystems 3730xl DNAAnalyzer. Results （ 1 ） The AR allele length ranged from 18 ～ 34 CAG repeat in healthy postmenopausal women. Average of CAG repeat was 23.34± 2.44 ; （2） There was a significant difference between healthy postmenopausal women and reproductive life in AR allele CAG repeat length （ P 〉 0.05 ）. Conclusions （ 1 ） Androgen receptor gene CAG length showed polymorphism in healthy postmenopausal women; （2）The CAG length was shorter in reproductive life than that in healthy postmenopausal women.
作者 郭志琴 李小鹰 曹剑 叶玲
机构地区 解放军总医院老年心血管一科 解放军总医院老年医学研究所分子生物实验室
出处 《中国分子心脏病学杂志》 CAS 2008年第2期99-102,共4页 Molecular Cardiology of China
关键词 雄激素受体基因 (CAG)n重复序列多态 更年期后女性 Androgen receptor gene CAG length polymorphism Healthy postmenopausal women
分类号 R195 [医药卫生—卫生统计学]
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参考文献10

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中国分子心脏病学杂志
2008年 第2期

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