Survivin在舌鳞癌中的表达及其与血管内皮生长因子的相关性

The Expression of Suvivin and its Correlation with VEGF in TSCC

目的:研究Survivin在舌鳞状细胞癌(tongue squamous cell carcinoma,TSCC)中的表达及其与血管内皮生长因子(vascular endothelial growth factor,VEGF)之间的相关性。方法:采用免疫组化pv9000法检测45例舌鳞癌组织Survivin、VEGF蛋白的表达。结果:Survivin、VEGF在舌鳞癌组织中表达水平为68.9%、64.4%。显著高于正常舌黏膜组(P<0.01)。Survivin表达与舌鳞癌组织学分级、TNM分期相关(P<0.05),与颈淋巴结转移密切相关(P<0.01)。VEGF表达与舌鳞癌TNM分期和颈淋巴结转移密切相关(P<0.05)。在舌鳞癌组织中Survivin、VEGF共同表达率为53.3%,其表达阳性程度呈显著正相关。结论:Survivin、VEGF的表达与舌鳞癌临床病理特征相关,Survivin、VEGF在舌鳞癌中起相互协同作用。

Objective： To study the expression of Survivin in TSCC and its correlation with VEGF. Methods： Immunohistochemistry （pv9000） method was adopted to detect the expression of Survivin and VEGF in 45 TSCC. Results： The expression of Survivin ,VEGF in TSCC was 68.9% ,64.4% ,respectively, significantly higher than those in normal tongue mucous membrane group （P〈0.01）. The expression of Survivin significantly correlated with pathological grade and TNM stages （P〈0.05）, and closely related with cervical lymphatic metastasis （P〈0.01）. The expression of VEGF was significantly correlated with TNM stages and cervical lymphatic metastasis （P〈0.05）. The co-expression rate of Survivin and VEGF was 53.3% in TSCC. Conclusions： Survivin and VEGF expression significantly correlated with the clinical pathological characteristics of TSCC, and they were corporated with each other in TSCC.