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热休克蛋白及其在骨关节炎中的研究进展

Advances in Research of Heat Shock Proteins in Osteoarthritis
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摘要 热休克蛋白(heat shock proteins,HSPs)又称应激蛋白,是生物体在不利因素刺激下产生的一族高保守蛋白质,具有分子伴侣功能,并参与了胚胎发育、细胞凋亡、免疫应答和调控细胞周期等生物学功能,对保护机体免受应激因素的损害具有重要作用。骨关节炎(osteoarthritis,OA)是一种退行性关节病,被认为是由生物学和化学因素共同作用导致的以软骨基质降解为特征的慢性疾病。
作者 陈伟 梁新华
出处 《口腔颌面外科杂志》 CAS 2008年第2期139-143,共5页 Journal of Oral and Maxillofacial Surgery
基金 国家自然科学基金(30300391) 口腔生物医学工程教育部重点实验课题
关键词 热休克蛋白 关节软骨 骨关节炎 软骨细胞 heat shock proteins osteoarthritis articular cartilage chondrocytes
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参考文献27

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