胃肠道恶性间质瘤27例临床分析

Malignant gastrointestinal stromal tumors:a clinical analysis of 27cases

目的探讨胃肠道恶性间质瘤的临床及病理特征。方法回顾性分析2000～2004年收治的27例胃肠道恶性间质瘤的临床及病理资料。结果胃肠道恶性间质瘤病人的临床表现以腹痛及消化道出血为主,发生部位以小肠及胃最为常见,术后均经病理学诊断为恶性。术后复发10例,死亡3例。结论肿瘤的大小、位置、核分裂像及免疫组化指标是判断胃肠道间质瘤良、恶性的重要指标。正确地诊断及合理地手术治疗对改善其预后有着重要意义。

Objective To study the clinical gastrointestinal Malignant stromal tumors（MGIST）. Methods Twenty-seven cases of clinical and pathological data of malignant MGIST admitted between 2000 and 2004 were analyzed retrospectively. Resuits The common clinical manifestation were abdominal pain and digestive tract bleeding. The most common tumor locations were small intestine and stomach. All cases were malignant pathological diagnosis after operation. Ten cases recurred after operation and three cases Died. Conclusion Tumor size,location,mitosis and immunohistochemical data are important indexes whether it is malignant. In order to improve the prognosis, it is of great importance to diagnose and treat GIST early and properly.