动脉插管化疗治疗晚期舌癌

Superselective arterial chemoembolization in treating advanced tongue cancinoma

目的探讨动脉插管诱导化疗在晚期舌癌治疗中的价值。方法对2例临床分期均为Ⅲ期的舌癌患者,由股动脉超选择插管至舌动脉注入顺铂150～200mg,5-FU1.5～2.0g以及平阳霉素50～80mg及数支明胶海绵条,14d后再施行舌颈联合根治术。结果栓塞化疗1周后肿瘤缩小,局部出现坏死、崩解或液化,无全身性不良反应,术后1年半随访,未发现肿瘤复发或转移。结论对中晚期舌癌患者术前进行选择性动脉栓塞化疗疗效好,不良反应少,值得推广。

Objective To evaluate the inducing chemotherapy through superselective arterial approch for patients with advanced tongue squamous cancinoma. Methods Two patients with advanced tongue cancinoma of Ⅲ stage were treated with lingual arterial superselective chemoembolization via femoral arterial approach with mixture of CDDP 150 - 200 mg , 5-FU 1.5 - 2.0 g, PYM 50 - 80 mg together with stripes of gelfoam sponge. Effects of the chemotherapy were evaluated and the tumors were undergone surgery 14 d after the chemoembolization. Results The tumor masses became smaller associated with necrosis, disaggregation and liquefaction with a week after the therapy accompanied by slight systemic side effects, and signs of recurrence or metastasis was not found after follow-up of 18 months. Conclusion Pre-operative superselective arterial chemoembolization would minimize complications, promote the effectiveness and be a good therapy for advanced tongue cancinoma.