伽玛刀治疗术后顽固性脑水肿的临床分析

Clinical Features of Refractory Cerebral Edema Developed after Gamma Knife Operations

目的:探讨伽玛刀治疗术后顽固性脑水肿发生的临床特点和相关影响因素。方法:总结432例颅内病变经伽玛刀治疗患者,发生顽固性脑水肿87例,以年龄,性别,病灶部位,90%病灶容积的边缘剂量,病灶的平均直径,病灶与正常脑组织的关系作为影响因素,分析伽玛刀治疗术后顽固性脑水肿的相关性。结果:伽玛刀治疗术后顽固性脑水肿的总发生率20.1%,其中以脑内动静脉畸形发生率最高,达41.9%;脑水肿发生率与年龄,病灶部位,90%病灶容积的边缘剂量,病灶平均直径,病灶与正常脑组织关系等因素密切相关。结论:伽玛刀治疗术后顽固性脑水肿发生率较高,值得临床重视。

Objective： To investigate the clinical features and related factors of refractory cerebral edema developed after gamma knife operations. Methods： Analyze the correlation between the influential factors and the refractory cerebral edema after gamma knife operations which including age, gender, lesion location, margin dose of 90 % lesion volume, average diameter of lesions, lesions and the normal brain tissue relation by summing up 432 cases of intracranial lesions patients with the gamma knife treatment, of which 87 cases take place refractory cerebral edema. Results： The total incidence rate of refractory cerebral edema after gamma knife treatment is 20.1%, among which brain arteriovenous malformation is highest, as much as 41.9 %. Furthermore it is closely related with age, lesion location, margin dose of 90 % lesion volume, average diameter of lesions and the relationship between lesion and the normal brain tissue. Conclusion： The incidence rate of refractory cerebral edema is quite high and should be pay enough attention in clinical work.