乳腺癌X线征象与微淋巴管生成的相关性研究

Correlation of Mammographical Signs with the Expression of VEGF-C and MLVD in Breast Cancer

目的:探讨浸润性乳腺癌的X线征象与血管内皮生长因子-C(VEGF-C)表达及微淋巴管密度(MLVD)的相关性。方法:回顾性分析资料完整的105例浸润性乳腺癌X线征象,应用免疫组化技术检测标本中VEGF-C、MLVD的含量,分析二者的相关性。结果:105例乳腺癌中68例VEGF-C阳性表达(占64.76%),其中55例高表达(占80.88%),MLVD平均为36.75±15.12;VEGF-C阳性组MLVD为39.63±12.25,VEGF-C阴性组MLVD为16.12±6.51,两组间差异有显著性意义(P<0.05)。乳腺癌X线征象:肿瘤直径≥2.0cm、毛刺征(+)、血管影增多增粗,腋窝淋巴结肿大与VEGF-C表达及MLVD含量密切相关(P<0.05)。结论:浸润性乳腺癌的部分X线征象可评价其组织中VEGF-C、MLVD的表达及微淋巴管生成情况,进而一定程度预测乳腺癌的恶性程度、转移及预后。

Objective：To discuss the correlation of mammographical signs with the expression of vascular endothelial growth factor C （VEGF-C） and microlymphatic vessel density （MLVD） in infiltrative ductal carcinoma of the breast. Methods：The plain film data of 105 cases with infiltrative ductal carcinoma of breast proved by pathology were retrospectively analyzed. Immunohistochemical technique was used to measure the expression of VEGF-C and MLVD in these tissues,and the correlation of imaging signs with them was analyzed. Results： VEGF-C were expressed in 68 of 105 patients （64.76%） ,including 55 （80.88%） cases with higher expression. MLVD was 36.75 ± 15.12, and it was 39.63±12.25 in the breast cancer of positive expression of VEGF while 16.12±6.51 in the breast cancer of negative expression of VEGF. The difference was remarkable （P〈0.05）. Some imaging signs of breast cancer,including size of lesion （≥2.0cm）, spiculated sign （＋）, vascularity, and axillary lymph node metastasis were closely related to the expression of VEGF-C and MLVD. Conclusion.. Some imaging signs of infiltrative ductal carcinoma of breast could reflect the expression of VEGF-C and MLVD and biological behavior of tumor cells. Therefore it could play a definite role in forecasting the prognosis and metastasis of breast cancer.