慢性心力衰竭患者血清三碘甲状腺原氨酸水平与脑利钠肽关系探讨

Correlation of free triiodothyronine with plasma brain natriuretic peptide in chronic heart failure

目的探讨慢性心力衰竭(CHF)患者血清三碘甲状腺原氨酸(T3)水平与脑利钠肽(BNP)的关系。方法测定114例慢性心力衰竭患者测定血清T3和BNP浓度。其中伴低T3血症的慢性心力衰竭患者60例(低T3组)和正常血T3的慢性心衰患者54例(正常T3组),观察两组BNP水平及6月内的再住院率。结果低T3组的心衰患者血清BNP水平均较正常T3组相同心功能级别者显著升高。低血T3组与正常血T3组心功能Ⅱ级、Ⅲ级、Ⅳ级的比较,BNP(pg/ml)分别为:280.4±80.2vs150±55.6,380±113.2vs300±63.5,570±133.3vs450.2±100.9,P<0.01,低T3组再住院率高。结论慢性心衰伴低T3患者,血清BNP升高更明显,再住院率高。

Objective To investigate relationship of free triiodothyronine （ FT3 ） levels and brain natriuretic peptide （BNP） in patients with chronic heart failure （CHF）. Method Plasma levels of T3, BNP were measured in 114 CHF patients with 60 chronic heart failure and low thyroid hormone （low T3 group） and 54 chronic heart failure and normal serum T3 level （ normal T3 group）. BNP levels and re-hospitalization rate between low T3 group and normal T3 group in six months were observed. Results The BNP level of low blood T3 group was significantly higher than that of normal blood T3 group of the same level of cardiac function. For low serum T3 and normal blood T3 group of cardiac function level Ⅱ, level Ⅲ ,level Ⅳ, the B N P （ pg,/ml ） were ：280.4 ± 80.2 vs 150 ± 55.6,380 ±113.2 vs 300 ± 63.5,570 ± 133.3 vs 450.2 ± 100.9, respectively, P 〈 0.01. The rate of rehospitalization within 6 months in low T3 goup was higher than that in control group. Conclusions Low T3 levels might promote the plasma BNP secretion in patients with chronic heart failure,and re-hospitallzation is higher than patients with normal T3 levels.