阿卡波糖对糖耐量减低患者血浆内皮素、一氧化氮、C反应蛋白的影响

The effects of Glucobay on endothelin,nitric oxide and C-reactive protein in impaired glucose tolerance patients

目的观察糖耐量减低患者应用阿卡波糖治疗前后血浆内皮素、一氧化氮、C反应蛋白水平变化。方法口服75g葡萄糖耐量试验筛查出糖耐量减低患者61例,随机分为阿卡波糖组(n=34)和安慰剂组(n=27),并对其进行为期15周的随机、双盲、安慰剂对照、阿卡波糖干预治疗试验。试验前后观察两组血浆内皮素、一氧化氮、C反应蛋白变化情况。结果糖耐量减低患者应用阿卡波糖治疗15周后,血浆内皮素、C反应蛋白显著下降,一氧化氮上升,而安慰剂组三者均无显著性改变。结论糖耐量减低患者应用阿卡波糖治疗后其血浆内皮素、一氧化氮、C反应蛋白水平可显著改善。

Objective To observe the changes of endothelin（ET） ,nitric oxide（NO） and C-reactive protein（CRP） before and after the Glueobay therapy in impaired glucose tolerance patients（1GT）. Methods 61 1GT patients were divided randomly into 2 groups：Glucobay group （n =34） and placebo group（ n =27 ） ;15 weeks later,the efficacy of Glucobay was compared. Results The levels of ET,CRP decreased and NO increased significantly in Glucobay group,but remained unchanged in placebo group. Coneluusion Glucobay cart significantly improve ET, NO, CRP level in IGT patients ,which means an additional effect of correcting inflammation and endothelial disturbance.