摘要
目的:考察雷公藤提取物及其指标成分雷公藤甲素在透皮制剂常用试剂中的溶解情况,研究在各溶剂中提取物溶解情况、指标成分溶解情况以及雷公藤提取物分散情况三者的关系。方法:运用沉淀法、指标成分含量测定法、粒径法对提取物溶解量、指标成分溶解量以及混悬液粒径进行测定。结果:①对提取物的溶解能力为:无水乙醇>异丙醇>油酸>肉豆蔻酸异丙酯>水>甘油;②对指标成分的溶解能力为:无水乙醇>异丙醇>油酸>肉豆蔻酸异丙酯>水>甘油;③混悬液粒径为:肉豆蔻酸异丙酯>油酸>无水乙醇>异丙醇。结论:①提取物溶解性能变化趋势与指标成分溶解性能变化趋势相同;②混悬液的粒径变化趋势与提取物溶解性能变化趋势基本呈反相关。
AIM： To investigate the dissolvability of thundergodvine extract（ Tripterygium wilfordii） and triptolide in different dissolvent in transdermal drug delivery system and to study the relationship among dissolvability of extract, and its active component and mean diameters of suspension. METHODS： To determine dissolvability of extract, dissolvability of active component and mean diameters by precipitation method, dissolvability of active component method and mean diameters method. RESULTS ： ① solvents in sequence of dissolvability of extract, alcohol, isopropanol, ethyl, IPM, water, glycerol; ② solvents in sequence of dissolvability of active component alcohol, isopropanol, ethyl, IPM, water, glycerol; ③ mean diameters of suspension in sequence： IPM, ethyl, alcohol, isopropanol. CONCLUSION： ① The change in dissolvability between extract and active component is identical ; ② The relationship between the changes in mean diameters and the dissolvent of active component is negative correlation on the whole.
出处
《中成药》
CAS
CSCD
北大核心
2008年第4期501-504,共4页
Chinese Traditional Patent Medicine
基金
江西省教育厅科学技术研究平台建设资助项目:雷公藤外用治疗类风湿性关节炎微乳凝胶的研究,项目文号:赣教技宇[2005]2
