摘要
目的:探讨了2型糖尿病肾病患者血清TGF-β1、脂联素水平的变化及意义。方法:分别应用ELISA和放射免疫分析对36例2型糖尿病肾病患者进行了血清TGF-β1、脂联素水平的检测,并与30名正常健康人作比较。结果:2型糖尿病肾病患者血清TGF-β1水平非常显著地高于正常人组(P<0.01),而脂联素水平则显著地低于正常人组(P<0.01),两者呈明显的负相关(r=-0.4012,P<0.05)。结论:检测2型糖尿病肾病患者血清TGF-β1和脂联素水平的变化可为2型糖尿病肾病患者的早期诊断、预防和治疗提供一种有效的手段。
Objective To study the clinical significance of changes of serum TGF - β1 and adiponectin levels in type 2 diabetics with ncphropathy. Methods Serum TGF - β1(with ELISA) and adiponccfin (with RIA) levels were determined in 36 patients with type 2 diabetic nephropathy and 30 controls. Results In the patients, the serum TGF - β1 levels were significantly higher and adiponectin levels were significantly lower than those in controls ( P 〈 0.01 ), levels of TGF - β1 and adiponcctin were mutually negatively correlated (r = - 0. 4012, P 〈 0.05). Conclusion Determination of serum TGF - β1 and adiponectin levels might be of use in the early diagnosis of type 2 diabetic ncphropathy.
出处
《放射免疫学杂志》
CAS
2008年第2期115-116,共2页
Journal of Radioimmanology
关键词
2型糖尿病肾病
转化生长因子-Β1
脂联素
type 2 diabetes nephropathy, transforming growth factor ( TGF - β1 ), adiponecfin