2型糖尿病肾病患者血清TGF-β_1、脂联素检测的临床意义

Clinical Significance of Determination of Serum TGF-β_1 and Adiponectin Levels in Type 2 Diabetics with Nephropathy

目的:探讨了2型糖尿病肾病患者血清TGF-β1、脂联素水平的变化及意义。方法:分别应用ELISA和放射免疫分析对36例2型糖尿病肾病患者进行了血清TGF-β1、脂联素水平的检测,并与30名正常健康人作比较。结果:2型糖尿病肾病患者血清TGF-β1水平非常显著地高于正常人组(P<0.01),而脂联素水平则显著地低于正常人组(P<0.01),两者呈明显的负相关(r=-0.4012,P<0.05)。结论:检测2型糖尿病肾病患者血清TGF-β1和脂联素水平的变化可为2型糖尿病肾病患者的早期诊断、预防和治疗提供一种有效的手段。

Objective To study the clinical significance of changes of serum TGF - β1 and adiponectin levels in type 2 diabetics with ncphropathy. Methods Serum TGF - β1（with ELISA） and adiponccfin （with RIA） levels were determined in 36 patients with type 2 diabetic nephropathy and 30 controls. Results In the patients, the serum TGF - β1 levels were significantly higher and adiponectin levels were significantly lower than those in controls （ P 〈 0.01 ）, levels of TGF - β1 and adiponcctin were mutually negatively correlated （r = - 0. 4012, P 〈 0.05）. Conclusion Determination of serum TGF - β1 and adiponectin levels might be of use in the early diagnosis of type 2 diabetic ncphropathy.