子宫内膜异位症患者治疗前后血清CA125、VEGF检测的临床意义

Clinical Significance of Determination of Changes of Serum CA125,VEGF Levels After Treatment in Patients with Endometriosis

目的:探讨了子宫内膜异位症患者治疗前后血清CA125、VEGF水平的变化及意义。方法:分别应用放免法和ELISA对36例子宫内膜异位症患者进行了血清CA125、VEGF检测,并与30名正常人作比较。结果:子宫内膜异位症患者在治疗前后血清CA125、VEGF水平均非常显著地高于正常人组(P<0.01),经治疗3个月后与正常人比较仍有差异(P<0.05)。结论:子宫内膜异位症患者的发生和发展与血清中CA125、VEGF水平密切相关。

Objective To explore the significance of changes of serum CA125, VEGF levels after treatment in patients with endometriosis. Methods Serum CA125 （ with RIA） and VEGF （with ELISA） levels were determined in 36 patients with endometriosis both before and after treatment as well as in 30 controls. Results Before treatment, the serum CA125, VEGF levels in the patients were significantly higher than those in the controls （ P 〈 0.01 ）. After 3 months of treatment, the levels dropped markedly, but still remained significantly higher（P 〈 0.05）. Conclusion Serum levels of CA125 and VEGF were closely related to the disease process in patients with chdometriosis.