冠心病患者血清hs-CRP和血浆脂联素检测的临床意义

Clinical Significance of Measurement of Changes of Serum hs-CRP and Plasma Adiponectin Levels After Treatment in Patients with Coronary Heart Diseases

目的:探讨了冠心病患者血清hs-CRP和血浆脂联素水平的变化及意义。方法:应用免疫比浊法和ELISA对68例冠心病患者进行测定,其中稳定型心绞痛31例,不稳定型心绞痛30例,急性心肌梗死7例,进行了血清hs-CRP和血浆脂联素水平测定,并与35名正常健康人作比较。结果:冠心病患者在治疗前血清hs-CRP水平非常显著地高于正常人组(P<0.01),而血清脂联素水平则显著地低于正常人组(P<0.01),急性心肌梗死组和不稳定型心绞痛组又高于稳定型心绞痛组(P<0.01)。经治疗后一个月血清hs-CRP与正常人比较无显著性差异(P>0.05)而脂联素水平与正常人比较仍有显著性差异(P<0.05)。结论:检测冠心病患者血清hs-CRP和血浆脂联素水平对冠心病的发生、发展以及疗效和预后均有重要的临床价值。

Objective To explore the signiticance of determination of serum has - CRP and plasma adiponectin leveLs after treatment in patients with coronary heart diseases. Methods Serum hs - CRP levels were determined with immuno - turbidity method and plasma adiponectin leveLs were determined with ELISA in 68 patients with coronary heart diseases （31 SAP, 30 UAP, 7AMI） and 35 controls. Results Before treatment, the serum levels of hs - CRP in patients with conomary heart diseases were signiticantly higher than those in controls （P 〈0.01 ）, while the plasma adiponectin levels were signiticantly lower （P 〈0.01 ）. Among the CHD patients, magnitude of the changes of the levels of hs - CRP and adiponectin in AMI and UAP groups was signiticantly large than that in SAP group （P 〈 0.01 ） . After treatment for one month, the serum levels of hs - CRP in the patients were not much different from those in the consols （P 〉 0.05 ）, but plasma adiponectin levels still remained significantly lower （P 〈 0.05）. Conclusion The serum leveLs of Ks - CRP and adiponcfin were closely related to the diseases process of CHD and were of great clinical importance.