摘要
目的观察尿毒症患者血清高敏C反应蛋白（HSCRP）及血液流变学指标，分析它们的关系及对疾病进展的影响。方法采用免疫比浊法测定高敏C反应蛋白，比浊法测定血浆纤维蛋白，全自动血液流变仪检测血液流变指标。结果与正常对照组相比高敏C反应蛋白、血浆纤维蛋白原（Fib）、全血高切粘度（200s^-1）、血浆粘度（100s^-1）红细胞聚集指数（EAI）、红细胞刚性指数（IR）和红细胞比容（HCT），有显著性差异（P〈0.01）。结论尿毒症患者血管处微炎症状态，这种微炎症状态与其血液流变性互为因果是尿毒症心血管系统并发症的危险因素。
Objective To observe serum high-sensitivityC-reaction protein and hem-orheology in uremic patients, to analysis the association between high sensitiv-ity C-reaction protein and hemorheology and their effect on the devolepment of uremic patient. Methods The immune turbidimetry method was employed to measure the level of high sensitivity C-reaction protein and the turbidimetry method wasemployed to measure the level ofplasma fibrinogen , the hemorh-eogical parameter of was measured with an automated blood viscometer. Results Compared with normal persons, uremic patients had significant differences in high sensitivity Creaction protein ,plasma fibrinogen （Fib） ,whole blood viscosity in high shear rat-es（200s^-1）, plasma viscosity（100s^-1）, erythrocyte aggregation index （EAI） , eryth-rocyte steel index （IR）and hematocrit（HCT） （P〈0.01）. Conclusion The vessels of uremic patients were in micro-inflammation state, the micro-inflammation state and hemorheology in uremic patients reflects mutual causality are the risk factors of Cardiovascular Complications of uremic.
