隐匿性哮喘患者血浆炎症标记物与肺小气道功能的关系

Correlation between Serum Levels of Inflammatory Biomarkers and Small Airway Ventilatory Function in Patients with Concealed Asthma

目的:探讨隐匿性哮喘(concealedasthma,CA)患者血浆炎症标记物与肺小气道功能的关系。方法:选择连续确诊的(经支气管激发试验)隐匿性哮喘急性发作期患者(n=30)行肺小气道功能测定,以ELISA方法测定其血中C-反应蛋白(CRP)、白细胞介素-6(IL-6)和IL-4水平。另选健康查体者(n=21)作为对照。结果:与对照组比较,CA急性发作期患者存在肺小气道功能减退(P<0.05);血中CRP、IL-6及IL-4水平显著升高(P<0.05),并与FEF25%-75%、FEF75%-85%呈负相关。结论:隐匿性哮喘患者存在肺小气道功能减退,血中炎症标记物水平显著升高,并与其小气道功能的减退呈负相关。

Objective：To investigate the correlation between the serum levels of inflammatory biomarkers and small airway ventilatory function in patients with concealed asthma （CA）. Methods：Consecutive patients （n=30） with CA confirmed by specific or non specific provocation test were included in this study and people with health-examination （n= 21） were choose as control. There lung function was determined and the C-reactive protein （CRP）,interleukin-6 （IL-6） and IL-4 was measured by enzyme-linked immunosorbent assays. Result：Compared to the control, the small airway ventilatory function of CA patients was impaired. The serum levels of CRP, IL-6 and TNF-α was significantly increased （P〈0.05） and there was a negative correlation between the levels of inflammatory biomarkers and FEF25%-75%,FEF75%-85%, P〈0.01）. Conclusion：Patients with concealed asthma have a impaired small airway ventilatory function and a higher serum level of CRP, IL-6 and IL-4.