多西紫杉醇联合奥沙利铂、甲酰四氢叶酸/5-氟尿嘧啶治疗晚期胃癌疗效分析

Effect of Docetaxel Combined with Oxaliplatin and Fluorouracil in Patients with Late Stage Gastric Cancer

目的观察多西紫杉醇(Docetaxe1)联合奥沙利铂(Oxaliplatin)、甲酰四氢叶酸(CF)/5-氟尿嘧啶(fluoroura-cil)治疗晚期胃癌的疗效及耐受性。方法全组32例患者,均经病理确诊。应用Docetaxel75mg/m2,静脉滴注1h,第1天,化疗前预处理;Oxaliplati135mg/m2,静脉滴注2h,第2天;CF200mg/m2,静滴2h,第1～5天,后5-Fu350mg/m2静滴4～6h,第1～5天,21d为1周期。结果全组CR2例、PR15例、SD10例、PD5例,总有效率53.1%。不良反应主要有骨髓抑制和消化系统反应。结论多西紫杉醇联合奥沙列铂、甲酰四氢叶酸/5-氟尿嘧啶治疗晚期胃癌疗效肯定,不良反应能耐受。

Objective To observe the therapeutic effect and toxicity of docetaxel combined oxaliplatin and fluorouracil in late stage gastric cancer patients. Methods All 32 cases were confirmed by pathological examination. Docetaxel 75 mg/m^2 iv drip dl ;Oxaliplatin 135 mg/m^2 iv drip d2;CF 200 mg/m^2 ,iv drip d1-5,5-Fu 350 mg/m^2 iv drip d1-5, every 3 weeks. Results All the patients can be valued, and 2 achieved complete response, 15 achieved partial response, 10 stable disease, and 5 patients showed progressive disease. The response rate of the total group was 53, 1%. The most common side effects were bone marrow restraint and gastrointestinal reactions. Conclusions Doeetaxel ＋ Oxaliplatin ＋ CF/5-Fu combination chemotherapy is an effective and tolerable regimen in patients with advanced gastric.