摘要
目的探讨根除幽门螺杆菌(Hp)对预防消化性溃疡再出血作用。方法对消化性溃疡并出血病人行急诊胃镜检查,取胃窦组织检测Hp。随机选择Hp阳性病人分为A、B两组,分别用洛赛克(20mg/次)+羟氨苄青霉素(750mg/次)和单独用洛赛克(20mg/次)治疗,每天2次,共2周。Hp阴性组(C组)单用洛赛克(20mg/次)治疗,每天2次,共2周。之后,三组病人再用洛赛克(20mg/次),一日一次,治疗2周。疗程结束,复查胃镜及检测Hp,并随访18个月。结果A、B、C三组病人经治疗后,溃疡愈合率分别为100%,968%和975%,三组之间相互比较无明显差异,(P>005)。A、B两组Hp根除率分别为833%和187%,两者比较有显著性差异(P<005)。随访18个月后,A、B两组的再出血率分别为27%和313%,两者比较有显著性差异(P<005),而C组再出血率为125%,分别与A、B两组比较,再出血率无显著性差异(P>005)。结论根除Hp能降低消化性溃疡再出血,所有Hp阳性的消化性溃疡并出血病人需要进行根除Hp治疗。
AIMS The aim of the present study was to examine whether eradication of Helicobacter pylori has any impact on the rebleebing in peptic ulcer diseases.METHODS All patients had emergency endoscopy,and tests for H.pylori proved to be positive in all.After discharge,patients with positive of H.pylori were randomized to receive either combination of Losec 20mg Bid and Amoxicillin 750mg Bid (Group A n=36) or Losec 20mg Bid alone (Group B n=32)for 2 weeks.Patients with negative of Helicobacter pylori were treated with Losec 20mg Bid (Group Cn=40) for 2 weeks.After discharge,all patients were treated with Losec 20mg Qd for 2 weeks.Endoscopy was performed after treatment ended to check for eradication of H.pylori.Then,all patients were followed for 18 months.RESULTS Ulcer healing rates were 100%(Group A) and 96.8%(Group B) and 97.5%(Group C).Through the comparison of the three groups respectively,ulcer healing rates were no difference (P>0.05).Helicobacter pylori eradication rates were 83.3%(Group A) and 18.7%(Group B).H.pylori eradication rates of Group A were significantly higher than that of Group B.Followed for 18 months,rebleeding rates were significantly lower in Group A (2.7%) than in Group B(31.3%) (p<0.05).However,comparison of Group A (Group B) with Group C,rebleeding rates were no significant difference (P>0.05).CONCLUSION Eradication of H.pylori significantly reduces the rates of rebleeding in peptic ulcer disease.So,eradication should be considered in all such patients in order to reduce rebleeding.
出处
《胃肠病学和肝病学杂志》
CAS
1997年第2期162-165,共4页
Chinese Journal of Gastroenterology and Hepatology