摘要
目的:为了寻求效佳、安全、短程根除幽门螺杆菌(Hp)的方法,对兰索拉唑(Lan)、法莫替丁(Fam)合用阿莫西林(Amo)的二联疗法进行了临床观察。方法:44例经胃镜检查证实为十二指肠溃疡患者、Hp阳性,随机分为二组分别接受Lan和Fam治疗。Lan组:Lan30mgBid×14天;Fam组:Fam20mgBid×14天,两组均同时服用Amo0.5gtid×14天。结果:停药4周,行胃镜检查及Hp测定,结果表明二组的溃疡愈合率及Hp根除率相近,分别为875%及85%;75%及70%。结论:本研究显示Lan和Fam加Amo的二联疗法具有缓解症状快、疗程短,副反应小等优点。
Aims In order to find out the method which is effective,safety and short time for eradication or Hp.The combined administration of Lansoprazole(Lan) of Famotidine (Fam)and Amoxicillin (Amo) were investigated for the patient with duodenal ulcer.Methods The 44 patients suffering from duodenal ulcer with Helicobacter pylori(Hp)positive are dividedinto two groups randomly.one was administered Lan 30mg Bid×14 days+Amo 0.5 tid×14 days;another Fam 20mg Bid×14 days+Amo 0.5 tid 14 days.No other drugs were eaten during treatment.Result Endoscopies were performed 4 weeks later to assess ulcer healing and Hp eradication.Ulcer healing rate:Lan group was 87.5%;Fam group 85%,Hp eradication rate:Lan group was 75%;Fam group 70%.There were no significant difference between Lan group and Fam group.Conclusion It is suggested Lan or Fam and Amo can quickening the healing of ulcer,achieving the high healing rate of ulcer and the high eradication rate of Hp,little side-effect,patient accepted.Therefore the combined application of Lan or Fam and Amo is considered as a quite ideal method to cure the Hp ulcer.
出处
《胃肠病学和肝病学杂志》
CAS
1997年第2期174-175,共2页
Chinese Journal of Gastroenterology and Hepatology
关键词
幽门螺杆菌
阿莫西林
十二指肠溃疡
兰索拉唑
Helicobacter pylori(Hp) Peptic ulcer Lansoprazole Famotidine Amoxicillin