短程联合用药根除幽门螺杆菌的疗效观察

THE EFFECT OF SHORT AND COMBINED ADMINISTRA- TION FOR THE ERADICATION OF HELICOBACTER PYLORI(Hp)

目的：为了寻求效佳、安全、短程根除幽门螺杆菌（Ｈｐ）的方法，对兰索拉唑（Ｌａｎ）、法莫替丁（Ｆａｍ）合用阿莫西林（Ａｍｏ）的二联疗法进行了临床观察。方法：４４例经胃镜检查证实为十二指肠溃疡患者、Ｈｐ阳性，随机分为二组分别接受Ｌａｎ和Ｆａｍ治疗。Ｌａｎ组：Ｌａｎ３０ｍｇＢｉｄ×１４天；Ｆａｍ组：Ｆａｍ２０ｍｇＢｉｄ×１４天，两组均同时服用Ａｍｏ０．５ｇｔｉｄ×１４天。结果：停药４周，行胃镜检查及Ｈｐ测定，结果表明二组的溃疡愈合率及Ｈｐ根除率相近，分别为８７５％及８５％；７５％及７０％。结论：本研究显示Ｌａｎ和Ｆａｍ加Ａｍｏ的二联疗法具有缓解症状快、疗程短，副反应小等优点。

Aims In order to find out the method which is effective,safety and short time for eradication or Hp.The combined administration of Lansoprazole(Lan) of Famotidine (Fam)and Amoxicillin (Amo) were investigated for the patient with duodenal ulcer.Methods The 44 patients suffering from duodenal ulcer with Helicobacter pylori(Hp)positive are dividedinto two groups randomly.one was administered Lan 30mg Bid×14 days+Amo 0.5 tid×14 days;another Fam 20mg Bid×14 days+Amo 0.5 tid 14 days.No other drugs were eaten during treatment.Result Endoscopies were performed 4 weeks later to assess ulcer healing and Hp eradication.Ulcer healing rate:Lan group was 87.5%;Fam group 85%,Hp eradication rate:Lan group was 75%;Fam group 70%.There were no significant difference between Lan group and Fam group.Conclusion It is suggested Lan or Fam and Amo can quickening the healing of ulcer,achieving the high healing rate of ulcer and the high eradication rate of Hp,little side-effect,patient accepted.Therefore the combined application of Lan or Fam and Amo is considered as a quite ideal method to cure the Hp ulcer.