原发性肝癌患者血液流变性改变的探讨

Explore the hemorrheological changes of patients with primary hepatic carcinoma

目的：探讨原发性肝癌血液流变学改变及临床意义。方法：测定４５例原发性肝癌患者外周静脉血血液流变学及纤维蛋白原指标，并以４９例肝炎后肝硬化和３６例正常人作对照。结果：肝癌组血液粘滞诸指标均显著高于肝硬化组和正常组，其中肝癌Ⅲ期组（ｎ＝１７，８２．３％患者伴有门脉癌栓形成和／或肝内外血行转移）又比肝癌Ⅱ期组（ｎ＝２８）变化明显。结论：原发性肝癌患者存在高粘滞综合症，它可能有助于门脉癌栓形成和肿瘤血行转移的发生；慢性肝病患者血液流变性检测可为肝癌早期诊断提供线索。

Aims:To explore the hemorrheological changes of patients with primary hepatic carcinoma and its clinical significance.Methods:We measured the changes of peripheral venous blood hemorrheological indexes and fibrinogen of 45 patients with primary hepatic carcinoma,and 49 patients with posthepatitis cirrhosis and 36 health adult as controls.Results:Plasma level of hemorrhelogical viscosity indexes of hepatic carcinoma group were sinificantly higher than those of liver cirrhosis group and normal control group;and also those of hepatic carcinoma group Ⅲ (n=17, 82.3% patients accompanied by portal vein carcinous thrombus and/or blood route metastasis) were higher than those of hepatic carcinoma group Ⅱ(n=28).Conclusions:Primary hepatic carcinoma often accompanies hyperviscosity blood syndrome,which may be of some help to the genesis of portal vein carcinous thrombus and metastasis;To measure hemorrheology indexes of chronic liver disease might give a clue to early diagnosis of hepatic carcinoma.