0.75uCi胶囊法^(14)C-UBT诊断幽门螺杆菌感染

0.75 uCi Capsular 14~ C-urea breath test for detection of H. pylori infection

目的评价０７５ｕＣｉ胶囊法１４Ｃ－尿素呼气试验（１４Ｃ－ＵＢＴ）诊断幽门螺杆菌（Ｈｐ）感染的准确性。方法６８１例患者接受１４Ｃ－ＵＢＴ检查。以其中８７例患者胃粘膜活检标本同时快速尿素酶试验和Ｇｉｅｍｓａ染色阳性或同时阴性为标准，评价１４Ｃ－ＵＢＴ２５分钟呼气样本１００ｄｐｍ／ｍｍｏｌＣＯ２为判断阳性阈值的准确性；以无活检资料的５９４例１４Ｃ－ＵＢＴ结果作回顾性分析，检验将１４Ｃ－ＵＢＴ＝１００ｄｐｍ／ｍｍｏｌＣＯ２定为判断Ｈｐ感染界限时，出现误诊的可能性。结果以胃粘膜活检结果为标准，１４Ｃ－ＵＢＴ诊断Ｈｐ感染的准确性为９６６％（８４／８７）；５９４例无活检资料者１４Ｃ－ＵＢＴ值范围为。－１７８０ｄｐｍ／ｍｍｏｌＣＯ２，仅５４％（３２／５９４）落在１００ｐｍ／ｍｍｏｌＣＯ２附近（８０－１２０ｐｍ／ｍｍｏｌＣＯ２），即误诊可能性小于６％。

Objective To evaluate the accuracy of 0.75uCi capsular14~C-urea breath test(14C-UBT) on the detection of H.pylori(Hp) infection.Methods 14 C-UBT was conducted in 681 subjects.The cut-off value of 14C-UBT at 25 min breath sample was evaluated in 87 subjects whose Hp infection status was confirmed both by rapid urease test and Giemsa stain of gastric biopsy,and the mis-diagnostic possibillity was estimated through a retro-spective analysis in 594 subjects without biopsy data.Results Taking the findings by gastric biopsy as a standard ,the accuracy of 14C-UBT was 96.6%(84/87);While in 594 subjects without gastric biopsy ,the value of 14C-UBT ranged 0～1780 dpm/mmol CO2 with only 5.9%(32/594) subjects falling on the point around 100 dpm/mmol CO2(80～120 dpm/mmol CO2),i.e.the possibility of misdiognostic was less than 6%.Conclusion 0.75 uci capsular 14C-UBT is highly accurate on the detection of Hp infection.