纤维蛋白元和冠心病共存其它心脏病的关系

THE RELATIONSHIP BETWEEN FIBRINOGEN AND CORONARY ARTERY DISEASE AND OTHER COEXISTING HEART DISEASE

测定665例住院患者（冠心病239例；冠心病合并其它心脏病40例；非冠心病心脏病238例和无心血管病148例）血浆纤维蛋白无（FG）进行分组分析。结果：冠心病及冠心病合并其它心脏病FG水平与冠心病是显著正相关，而且不受是否合并有其它心脏病的影响。表明FG是冠心病的独立危险因子，而且FG≥3．5g／L与冠心病和冠心病共存其它心脏病呈显著正相关。

Plasma fibrinogen levels were measured in 665 patients; 239 with coronary artery disease (CAD), 40 with coexisting heart disease, 238 with noncoronary heart disease and 148 healthy controls. The increase in fibrinogen levels associated with CAD was similar in patients with and without coexisting heart disease. The results detnonsrate a significant positive relationship between the fibrinogen levels and the presence of CAD, irrespective of a possible influence from other Cardiac disease. The results support the hypothess that fibrinogen plays a pathogenetic role, and can be considered an independent risk factor of CAD. The trials indicate that a plasma fibrinogen level in excess of approximately 3. 5g/L is a strong independent risk factor for coronare anery disease.