A型肉毒毒素缓解脑瘫痉挛的适宜剂量与相关因素的研究

Suitable Dose and Correlation Factors in Treatment of Spastic Cerebral Palsy by Botulinum Toxic A Block

目的探讨A型肉毒毒素（BTX-A）缓解脑瘫痉挛的适宜剂量与程度及与其他因素的关系。方法对39例脑瘫患儿采用BTX-A局部注射缓解痉挛。结果23例患儿治疗后效果良好,其中男性15例、女性8例,年龄33～145个月,平均（60.7±26.9）个月。BTX-A的适宜剂量与患儿的性别、年龄、体重、诊断分型、粗大运动功能分级（GMFCS）、致病因素、注射点数目无相关性,与术前改良Ashworth量表（MAS）评分呈线性正相关。结论BTX-A可缓解脑瘫患儿的痉挛,注射剂量与MAS评分呈正相关。

Objective To investigate the optimal dose of botulinum toxic A （BTX-A） for releasing spasticity of cerebral palsy （CP） and related factors. Methods 39 children with CP was treated by BTX-A injected in local muscles to release the spasticity. Resuits After treatment, 23 children had good curative effect. In them, 15 cases were male, 8 cases were female, the mean age was 60.7±26.9 months （range 33 to 145 months）. There was no correlation between the optimal unit dose of BTX-A and those including sex, age, body weight, diagnosis type, degree of Gross Motor Function Classification System （GMFCS）, etiological factor and the injections. There was a linear positive correlation between the optimal unit dose of BTX-A and the score of Modified Ashworth Scale （MAS）. Conclusion BTX-A can release the spasticity of CP children, the injecting dose is correlated with MAS score.