摘要
为评价H2R激动剂甲双咪胍（impromidine）在哮喘气道炎症防治中的作用，应用该药治疗哮喘患者18例，观察治疗前和治疗6周后肺功能（FEV1％）、支气管高反应性（BHR）和血清嗜酸粒细胞阳离子蛋白（ECP）水平变化。结果发现各指标均有显著改善，FEV1％显著上升（P＜0．05），BHR显著下降（P＜0．05～0．01），ECP显著降低（P＜0．01）。结果提示甲双咪胍可主要作为抗气道炎症药物用于哮喘防治，具有良好的临床应用价值。
In order to explore the therapeutic effects of H2R agonist impromidine on asthmatics, the changes in bronchial responsiveness (BHR), lung function (FEV1% ), and serum eosinophil cationic protein (ECP) were observed before and after six weeks of therapy. The results show that BHR decreased (P＜0. 01), lung function improved (P＜0.05), and serum ECP levels were reduced considerably (P＜0.01). These results suggest that impromidine may be used as an anti-inflammation drug in the treatment of asthma.
出处
《中国现代医学杂志》
CAS
CSCD
1997年第8期1-2,共2页
China Journal of Modern Medicine
关键词
哮喘
肺功能
甲双咪胍
药物疗法
Asthma
Bronchial hyper-responsiveness
Lung function
Eosinophil cationic protein
Impromidine
