急性脑梗死患者血浆纤维蛋白原和C反应蛋白水平的改变及其与病情和预后的关系

Change and relationship between the levels of plasma fibrinogen and C-reactive protein and pathogenetic condition and prognosis in patients with acute cerebral infarction

目的探讨急性脑梗死(ACI)患者血浆纤维蛋白原(Fib)和C反应蛋白(CRP)水平的改变及其与病情和预后的关系。方法检测86例脑梗死患者(CI组)、27例腔隙性脑梗死患者(LCI组)和48名健康人(正常对照组)的血浆Fib及CRP含量。在CI患者入院当天和4周时进行临床神经功能缺损程度评分(NDS)评定。结果CI组和LCI组血浆Fib、CRP水平和异常率明显高于正常对照组(均P<0.01);NDS重型患者血浆Fib、CRP含量明显高于中型、轻型患者(均P<0.01);中型患者血浆CRP含量显著高于轻型患者(P<0.01)。血浆Fib和CRP含量异常组患者住院4周时显著进步和进步的比率明显低于正常对照组(均P<0.01),而无变化和死亡的比率明显高于正常对照组(均P<0.01)。结论ACI患者血浆Fib和CRP水平均明显升高,病情重的患者升高更明显;血浆Fib、CRP含量升高的患者预后较差。

Objective Explore the change and relationship between the levels of plasma fibrinogen （Fib） and C-reactive protein （CRP） and pathogenetic condition and prognosis in patients with acute cerebral infarction （ACI）. Methods The plasma levels of Fib and CRP of 86 cerebral infaction patients （CI group）, 27 lacuna cerebral infarction patients （ LCI group） and 48 health adults （ NC group） were measured. All patients were scored at first day and fourth week by clinical neurological function deficit scores （NDS） when admitted hospital. Results The levels of plasma Fib and CRP and the abnormal rate of CRP in the CI group and LCI group were higher than those of the NC group （ all P 〈 0. 01 ）. The levels of plasma Fib and CRP in the patients of NDS in heavy-duty were higher than those in the medium-duty and slight-duty patients （ all P 〈 0. 01 ）. The level of plasma CRP in the medium-duty patients was higher than that in slight-duty patients （P 〈 0. 01 ）. The rats of significant improvement and improvement in the group with abnormal plasma levels of Fib and CRP were lower than those in the normal group at fourth week （ all P 〈 0.01 ）. Conclusions The levels of plasma Fib and CRP are significantly increased in the patients with ACI, and the higher levels of plasma Fib and CRP, the more serious pathogenetic condition of patients. The prognosis of ACI patients with high levels of plasma Fib and CRP will be worse.