犬急性胃黏膜损伤的超声造影研究

Investigation of ultrasound contrast sonogram for acute gastric mucosa injury in dogs

目的研究急性胃黏膜损伤的超声造影声学表现。方法成年杂种犬16只,随机分为正常对照组和实验组。实验组建立急性胃黏膜损伤模型。两组犬经胃管注入新型胃肠超声造影剂后超声观察检测,分别记录超声声像图,然后开腹取胃,切取胃壁组织,制片染色,光镜下观察,并与超声声像图对照。结果超声声像图上,对照组犬胃腔充盈良好,胃壁结构层次清晰,即显示"强-弱-强-弱-强"五层回声;与对照组相比,实验组犬胃窦部胃壁明显增厚,第1、第2及第3层混为一层,且回声增强。结论应用胃肠超声造影检查可清晰显示正常犬及急性胃黏膜损伤模型犬胃壁的结构层次,提示超声造影对急性胃黏膜损伤有一定的诊断价值。

Objective To investigate the manifestations of ultrasound contrast sonogram in acute gastric mucosa injury. Methods Totally 16 adult hybird dogs were randomized into a normal control group and an experimental group. Acute gastric mucosa injury models were made in the experimental group. The gastric ultrasound sonogram was observed and recorded after each dog was injected with the new type UCA through gastric tubes. The stomaches of the dogs in the two groups were cut out, and their stomach tissues were cut into slices, dyed, and observed under microscope, which would be compared with the sonogram. Results The ultrasound sonogram showed that the stomaches of dogs in the control group were filled with UCA well, the structure of gastric wall could display clearly on 5 layers -＂strong-weak-strong-weak-strong＂. Compared with that in the control group, the sonogram of the experimental gastric antrum wall in dogs displayed much thicker, and the first, second and three-layer were mixed with each other resulting in more strengthened echo. Conclusion The structure of gastric wall in the normal and acute gastric mucosa injury of dogs could display clearly by gastrointestinal contrast ultrasound, which has a diagnostic value for acute gastric mucosa injury.