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苯那普利对兔髂动脉球囊损伤后内膜增生的影响 被引量:4

Effect of Lotension on Intimal Proliferation after Baloon Injury of Rabbit Iliac Artery
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摘要 为了探讨髂动脉内膜剥脱术后再狭窄的预防,将28只兔随机分为苯那普利组和对照组,行右髂动脉内膜球囊剥脱术。术后30天处死动物,作病理形态学检查及流式细胞术测定。结果表明,苯那普利组损伤血管内膜厚度小于对照组,而管腔面积大于对照组(P均<0.001)。治疗组血管壁细胞增殖期细胞数明显低于对照组(P均<0.001)。提示,苯那普利能抑制动脉球囊损伤后血管平滑肌细胞增殖,减轻内膜增生。 In order to study the prevention of restenosis after illac arterial endothelial debridement, 28 rabbits were randomized into two groups. In the treatment group( n =14), Lotension 10 mg/d was taken orally from 7 days before to 30 days afer endothelial debridement. In control group( n =14), no Lotension was taken. All rabbits underwent endothelial debridement of the right iliac artery and were killed 30 days later. Pathomorphological examination and flow cytometry were carried out. The result demonstrated that Lotension significantly reduced the thickness of iliac arterial intima and increased the luminal cross sectional area of the arteries compared with the control group(all P <0.001). It also showed that the number of proliferous cells of the arterial wall in the treatment group was significantly lower than that in the control group (all P <0.001). In conclusion, Lotension could effectively inhibit the hyperplasia of smooth muscle cells in the arterial intima and significantly reduced intima thickness.
出处 《南京医科大学学报(自然科学版)》 CAS CSCD 1997年第5期439-442,共4页 Journal of Nanjing Medical University(Natural Sciences)
关键词 苯那普利 骼动脉 内膜剥脱术 流式细胞术 Lotension lliac arterial endothelial debridement Intima proliferation flow cytometry rabbit
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参考文献2

  • 1杨树森,心血管病学进展,1995年,16卷,165页
  • 2刘利,心血管病学进展,1993年,14卷,280页

同被引文献50

  • 1[1]Benes V,Zabramski JM,Boston M,et al.Effect of intraarterial antifibrinolytic agents on autologous arterial emboli in the cerebral circulation of rabbits.Stroke,1990,21:1594-1599.
  • 2[2]Zhao BQ,Suzuki Y,Kondo K,et al.A novel MCA occlusion model of by photothrombotic ischemia with cyclic flow reductions:development of cerebral hemorrhage induced heparin.Brain Res Brain Res Protoc,2002,9:85-92.
  • 3Thompson JE. The evolution of surgery for the treatment and prevention of stroke. The Willis Lecture[J]. Stroke,1996, 27:1427 - 1434.
  • 4Marek JM, Koehler C, Aguirre ML, et al. The histological characteristics of primary and restenosis carotid plaque[J]. J Surg Res, 1998,74:27 -33.
  • 5Drechsel S, Bertel O, Lafont A. Mechanisms and preservation of restenosis after coronary angioplasty[J]. Schweiz Med Wochenschr, 1998,128( 13 ) :497 - 507.
  • 6Waksman R, Rodriguez JC, Robinson KA, et al. Effect of intravascular irradiation on cell proliferation, apoptosis,and vascular remodeling after balloon overstretch injury of porcine coronary arteries[J]. Circulation, 1997, 96(6):1944 - 1952.
  • 7Vaughan DE. Angiotensin and vascular fibrinolytic balacen[J]. Am J Hypertens, 2002, 15: 3S - 8S.
  • 8Langford El, Brown AS, Wainurig R J, et al. Inhibition of platelet activity by S-nitrosoglutathione during coronary angioplasty[J]. J Lancet,1994,344(8935): 1458.
  • 9Dempsey B J, Roy MW, Meyer K, et al. Development of cyclooxygenase and lipoxygenase metabolites of arachidonic acid after transient cerebral ischemia[J]. J Neurosury,1996, 64: 118.
  • 10Umemura K, Watanabe S, Kondo K, et al. Inhibitory effect of prostaglandin E1 on intimal thickening following photochemically induced endothelial injury in the rat femoral artery[J]. Atherosclerosis 1997,130(1 - 2): 11 -16.

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