摘要
用单能定量CT(QCT)检测激素对骨密度的影响并验证其准确性。采用成兔20只分为Ⅰ组正常对照,Ⅱ、Ⅲ、Ⅳ、Ⅴ组为激素组,分别肌肉注射不同剂量的强的松龙。每次注射前称体重,第3、6周分别用QCT测定股骨上段松质骨密度。最后进行灰重及骨钙含量的测定。结果:体重,Ⅰ组有上升趋向,Ⅱ、Ⅲ组有下降趋向。两者有显著差异(P<0.05)。股骨上段松质骨密度和骨灰重及骨钙含量Ⅱ、Ⅲ组与Ⅰ组比较有下降,有显著差异(P<0.05)。Ⅳ、Ⅴ组由于相继死亡,未作统计。结论:激素可导致骨质疏松,并可用单能QCT的方法去测定。
Objective∶ The effect of bone mineral density after injection of cortical hormone was determined by quantitative CT(QCT) and precision of QCT was evaluated. Materials and Methods∶ 20 adult rabbits were divided into five groups at random. Group Ⅰ was normal subjects, while in Groups Ⅱ, Ⅲ, Ⅳ, and Ⅴ, injections into gluteal muscle of prednisolone were done with 1.2 mg/kg, 2.5 mg/kg, 5 mg/kg, and 7 mg/kg respectively, and twice a week, six weeks in succession. Weights were measured before every injection. Bone mineral densities of upper femur were measured by QCT respectively on third week and sixth week. At last the weight of bone ash and calcium content were measured. Results∶ The mean weight of rabbits in Group Ⅰ and Groups Ⅱ, Ⅲ were significant ( P <0.05), weight of Group Ⅰ slowly increased, and Groups Ⅱ, Ⅲ slowly reduced. Bone mineral densities, the weight of bone ash and calcium content all reduced in Groups Ⅱ and Ⅲ. They were significant ( P <0.05) compared with Ⅰ. Because Group Ⅳ, Ⅴ died before the data were collected, their statistics is not available. Conclusion∶ steroids will result in osteoporosis and this might be measured by single energy QCT.
出处
《南京医科大学学报(自然科学版)》
CAS
CSCD
1997年第5期465-467,共3页
Journal of Nanjing Medical University(Natural Sciences)