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CD4^+CD25^(high)调节性T细胞与器官免疫耐受

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摘要 已经证明器官移植受者体内存在抑制性或调节性细胞，能下调抗原特异性的T细胞反应，进而有利于移植物特异性免疫耐受。1995年Sakaguchi^[1]首次报道，表达IL-2受体α链（CD25）的CD4^＋T细胞亚群的数量的减少和功能的缺陷可引起自身免疫性疾病，具有免疫调节作用。这群高表达CD25的细胞被命名为调节性T细胞（regulatory T cells,Treg），它们在器官移植耐受的诱导和维持中起重要作用。本文主要阐述CD4^＋CD25^high调节性T细胞的研究进展及其与临床器官移植的关系。
作者 王振 田莹
机构地区 解放军总医院第二附属医院全军器官移植中心 海军医学研究所
出处 《海军医学杂志》 2008年第1期90-92,共3页 Journal of Navy Medicine
关键词 CD4 CD25 CD4^+CD25^HIGH 调节性T细胞 器官免疫 耐受
分类号 R392.4 [医药卫生—免疫学] R392 [医药卫生—免疫学]
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参考文献18

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二级参考文献9

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海军医学杂志
2008年 第1期

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