自制CZ-1液对兔心肌组织低温延时保存的生化学指标观察

The changes in levels of ATP and mitochondria Ca^(2+) in rabbit hearts during cold storage with CZ1 solution

研制出我国自制的多种改良的UW液，是摆在移植界的一大课题。我院于1992年始研制成长征-1号多器官保存液（简称CZ-1液），同时对心肌组织0、6、12、18、24小时冷冻保存后的生化学指标作了观察。结果表明：与UW液比较，CZ-1液0、12、18、24小时冷冻保存兔心肌组织ATP含量无明显差别。而CZ－1液冷冻保存心肌线粒体Ca2＋超载明显缓于UW液。文章认为从生化指标变化来说，我们自制的CZ-1液与UW液效果基本一致，而部分指标如减缓心肌线粒体Ca＋2超载方面来说，优于UW液。

An alternative solution called CZ-1 solution in 1992 was developed. The changes in levels of ATP and mitochondria Ca^(2+) were observed in rabbit hearts infused with UW solution and CZ-1 solution at 0、6、12、18、24h of cold storage, respectively, The results showed that no statistical significance was found in ATP level between UW and CZ-1 solution. CZ-1 solution was more effective in preventing the mitochondria calcium accumulation than UW solution.